In the past concepts of experimental immunogenic uveitis, immediate and delayed types of hypersensitivity seemed to be fairly clear-cut phenomena.
But it is now apparent that many hypersensitivity reactions are not such clear-cut, they are often mixed and a number of basic mechanisms act in the development of tissue lesion of the uvea which is a shock tissue to experimentally administered foreign proteins, autogenous tissue, microorganism and its products.
The cellular reaction in immunogenic uveitis has been studied by many investigators; Delayed Arthus reaction could be occurred by a single intravitreal injection of the foreign protein, and both antibody-mediated hypersensitivity and delayed type of hypersensitivity also contributed to the ultimate Arthus reaction. It appeared probably that the autoimmune ocular reaction and the recurrent type of uveitis were of the delayed type of hypersensitivity. Much remains unanswered.
Historical review of experimental immunogenic uveitis also is presented.
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